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Showing posts with label What is. Show all posts
Showing posts with label What is. Show all posts

What is Multiple Myeloma ?

Written By share_e on Monday, March 12, 2012 | 5:31 PM

Definition

Multiple myeloma is cancer of the plasma cells in bone marrow.

Symptoms

  • Bleeding problems
  • Bone or back pain
  • Increased susceptibility to infection
  • Symptoms of anemia (such as tiredness, shortness of breath, and fatigue)
  • Unexplained fractures

Causes & Risk Factors

Plasma cells help the body's immune system fight disease by producing substances called antibodies. In multiple myeloma, plasma cells grow out of control and form tumors in the bone marrow.

The excess growth of plasma cells interferes with the body's ability to make red blood cells, white blood cells, and platelets. This causes anemia, which makes a person more likely to get infections and have abnormal bleeding.

As the cancer cells grow in the bone marrow, they can cause pain and destruction of the bones. If the bones in the spine are affected, it can put pressure on the nerves, resulting in numbness or paralysis.

Multiple myeloma mainly affects older adults. A history of radiation therapy raises your risk for this type of cancer.

Tests & Diagnostics

Blood tests can help diagnose this disease. They may include:
  • Blood chemistry (CHEM 20) may show increased levels of calcium, total protein, and abnormal kidney function
  • Complete blood count (CBC) reveals low numbers of red and white blood cells and platelets
  • Serum protein electropheresis (SPEP)
  • Urine protein electrophoresis (UPEP) or Bence-Jones protein analysis
  • Quantitative immunoglobulins (nephelometry)
Bone x-rays show fractures or hollowed out areas of bone. If your doctor suspects this type of cancer, a bone marrow biopsy will be performed.

Treatments

The goal of treatment is to relieve symptoms.

People who have mild disease or a questionable diagnosis are usually carefully monitored without treatment. Some people have a slow-developing form of multiple myeloma that takes years to cause symptoms.

Treatment begins when the disease becomes worse or causes symptoms.

Chemotherapy and radiation therapy may be performed to relieve bone pain or treat a bone tumor.

Bone marrow transplantation in younger patients has been shown to increase disease-free and overall survival, but it has significant risks.

Medications for multiple myeloma include decadron, melophalan, thalidomide, lenalidomide (Revlimid), and bortezomib (Velcade). Bisphosphonates are used to prevent fractures.
People with multiple myeloma should drink plenty of fluids to prevent dehydration and help maintain proper kidney function. They should also be cautious when having x-ray tests that use contrast dye.
Chemotherapy and transplants rarely lead to a permanent cure.

Complications

Kidney failure is a frequent complication. Other complications may include:
  • Bone fractures
  • Increased chances for infection (especially pneumonia)
  • Paralysis from tumor or spinal cord compression

Prevention

There are no clearly-established risk factors for multiple myeloma and it is possible that a combination of factors interact to cause the disease. Thus, there is no method for preventing multiple myeloma. 
5:31 PM | 0 comments | Read More

What is Osteoarthritis ?

Definition

Osteoarthritis (OA) is the most common joint disorder.

Symptoms

The symptoms of osteoarthritis include:
  • Deep aching joint pain that gets worse after exercise or putting weight on it, and is relieved by rest
  • Pain that is worse when you start activities after a period of no activity
  • Over time, pain is present even when you are at rest
  • Grating of the joint with motion
  • Increase in pain during humid or moist weather
  • Joint swelling
  • Limited movement
  • Muscle weakness around arthritic joints
Some people might not have symptoms.

Causes & Risk Factors

In osteoarthritis, the cushioning (cartilage) between the bones wears away in the joints. As osteoarthritis gets worse, the cartilage disappears and bone rubs on bone. Bony spurs or growths usually form around the joint. The ligaments and muscles around the joint loosen and become weaker.

Often, the cause of OA is unknown. It is mainly related to aging, but other factors can also lead to OA.
  • Osteoarthritis tends to run in families
  • Being overweight increases the risk
  • Fractures or other joint injuries can lead to osteoarthritis later in life
  • Long-term overuse at work or in sports can lead to osteoarthritis
Medical conditions that can lead to osteoarthritis include:
  • Bleeding disorders that cause bleeding in the joint, such as hemophilia
  • Disorders that block the blood supply near a joint, such as avascular necrosis
  • Other types of arthritis, such as chronic gout, pseudogout, or rheumatoid arthritis
The symptoms of osteoarthritis usually appear in middle age and almost everyone has them by age 70. Before age 55, the condition occurs equally in men and women. After age 55, it is more common in women.

Tests & Diagnostics

A physical exam can show:
  • Joint movement may cause a cracking (grating) sound
  • Joint swelling (bones around the joints may feel larger than normal)
  • Limited range of motion
  • Tenderness when the joint is pressed
  • Normal movement is often painful
No blood tests are helpful in diagnosing osteoarthritis.
An x-ray of affected joints will show a loss of the joint space. In advanced cases, there will be a wearing down of the ends of the bone and bone spurs.

Treatments

The goals of treatment are to:
  • Increase the strength of the joints
  • Maintain or improve joint movement
  • Reduce the disabling effects of the disease
  • Relieve pain
The treatment depends on which joints are involved.

MEDICATIONS
Over-the-counter pain relievers can help with symptoms. Most doctors recommend acetaminophen (Tylenol) first, because it has fewer side effects than other drugs.

If your pain continues, your doctor may recommend nonsteroidal anti-inflammatory drugs (NSAIDs). These drugs help relieve pain and swelling. Types of NSAIDs include aspirin, ibuprofen, and naproxen.

However, long-term use of NSAIDs can cause stomach problems, such as ulcers and bleeding. These drugs may also increase the risk for heart attacks and strokes.

The prescription drug, Celebrex (a COX-2 inhibitor) may work as well as other NSAIDs. Because of a risk for heart attacks and stroke, it is given only at the lowest possible dose for the shortest possible period of time.

Corticosteroids injected right into the joint can also be used to reduce swelling and pain. However, relief only lasts for a short time.

Many people use over-the-counter remedies such as glucosamine and chondroitin sulfate. There is some evidence that these supplements can help control pain, although they do not seem to grow new cartilage. Some doctors recommend a trial period of 3 months to see whether glucosamine and chondroitin work.

Capsaicin (Zostrix) skin cream may help relieve pain. You may feel a warm, stinging sensation when you first apply the cream. This sensation goes away after a few days of use. Pain relief usually begins within 1 - 2 weeks.

Artificial joint fluid (Synvisc, Hyalgan) can be injected into the knee. It may relieve pain for 3 - 6 months.

LIFESTYLE CHANGES
Exercise helps maintain joint and overall movement. Ask your health care provider to recommend an appropriate home exercise routine. Water exercises, such as swimming, are especially helpful.

Other lifestyle recommendations include:
  • Applying heat and cold
  • Eating a healthy, balanced diet
  • Getting rest
  • Losing weight if you are overweight
  • Protecting the joints
People whose work is causing stress in certain joints should find ways to reduce trauma. You may need to adjust the work area or change work tasks.

PHYSICAL THERAPY
Physical therapy can help improve muscle strength and the motion at stiff joints. Therapists have many techniques for treating osteoarthritis. If therapy does not make you feel better after 3 - 6 weeks, then it likely will not work at all.

BRACES
Splints and braces can sometimes support weakened joints. Some prevent the joint from moving; others allow some movement. You should use a brace only when your doctor or therapist recommends one. Using a brace the wrong way can cause joint damage, stiffness, and pain.

SURGERY
Severe cases of osteoarthritis might need surgery to replace or repair damaged joints. Surgical options include:
  • Arthroscopic surgery to trim torn and damaged cartilage
  • Changing the alignment of a bone to relieve stress on the bone or joint (osteotomy)
  • Surgical fusion of bones, usually in the spine (arthrodesis)
  • Total or partial replacement of the damaged joint with an artificial joint (knee arthroplasty, hip arthroplasty)

Drugs

Patients with mild OA may be treated only with pain relievers such as acetaminophen (i.e., Tylenol). Most patients with OA, however, are given nonsteroidal anti-inflammatory drugs (NSAIDs). These include compounds such as ibuprofen (e.g., Motrin, Advil), ketoprofen (e.g., Orudis), and naproxen (e.g. Naprosyn). NSAIDs have the advantage of relieving slight inflammation as well as pain. Patients taking NSAIDS, however, may experience side effects, including stomach ulcers, sensitivity to sun exposure, kidney disturbances, and nervousness/anxiety or depression. Topical capsaicin cream (e.g., AthriCare) may provide relief when applied to affected areas.

Some OA patients are treated with corticosteroids, which are injected directly into the joints to reduce inflammation. As of 2001, studies were being conducted regarding the use of hyaluronic acid, which is more commonly injected into the knee. Because the joint naturally contains some hyaluronic acid (for joint lubrication), the addition of extra hyaluronic acid can protect the joint, in some cases, for six months to one year.

Alternative Therapies

For more information and support, see arthritis resources.

Complications

  • Adverse reactions to drugs used for treatment
  • Decreased ability to perform everyday activities, such as personal hygiene, household chores, or cooking
  • Decreased ability to walk
  • Surgical complications
5:15 PM | 0 comments | Read More

What is Migraine Headache ?

Definition

A migraine is a common type of headache that may occur with symptoms such as nausea, vomiting, or sensitivity to light. In many people, a throbbing pain is felt only on one side of the head.
Some people who get migraines have warning symptoms, called an aura, before the actual headache begins. An aura is a group of symptoms, usually vision disturbances, that serve as a warning sign that a bad headache is coming. Most people, however, do not have such warning signs.

Symptoms

Vision disturbances, or aura, are considered a "warning sign" that a migraine is coming. The aura occurs in both eyes and may involve any or all of the following:
  • A temporary blind spot
  • Blurred vision
  • Eye pain
  • Seeing stars or zigzag lines
  • Tunnel vision
Not every person with migraines has an aura. Those who do usually develop one about 10 - 15 minutes before the headache. However, it may occur just a few minutes to 24 hours beforehand.


Migraine headaches can be dull or severe. The pain may be felt behind the eye or in the back of the head and neck. For many patients, the headaches start on the same side each time. The headaches usually:
  • Feel throbbing, pounding, or pulsating
  • Are worse on one side of the head
  • Start as a dull ache and get worse within minutes to hours
  • Last 6 to 48 hours
Other symptoms that may occur with the headache include:
  • Chills
  • Increased urination
  • Fatigue
  • Loss of appetite
  • Nausea and vomiting
  • Numbness, tingling, or weakness
  • Problems concentrating, trouble finding words
  • Sensitivity to light or sound
  • Sweating
Symptoms that may linger even after the migraine has gone away include:
  • Feeling mentally dull, like your thinking is not clear or sharp
  • Increased need for sleep
  • Neck pain

Causes & Risk Factors

A lot of people get migraines -- about 11 out of 100. The headaches tend to first appear between the ages of 10 and 46. Occasionally, migraines may occur later in life in a person with no history of such headaches. Migraines occur more often in women than men, and may run in families. Women may have fewer migraines when they are pregnant. Most women with such headaches have fewer attacks during the last two trimesters of pregnancy.


A migraine is caused by abnormal brain activity, which is triggered by stress, certain foods, environmental factors, or something else. However, the exact chain of events remains unclear.


Scientists used to believe that migraines were due to changes in blood vessels within the brain. Today, most medical experts believe the attack actually begins in the brain itself, where it involves various nerve pathways and chemicals. The changes affect blood flow in the brain and surrounding tissues.


Migraine attacks may be triggered by:
  • Alcohol
  • Allergic reactions
  • Bright lights
  • Certain odors or perfumes
  • Changes in hormone levels (which can occur during a woman's menstrual cycle or with the use of birth control pills)
  • Changes in sleep patterns
  • Exercise
  • Loud noises
  • Missed meals
  • Physical or emotional stress
  • Smoking or exposure to smoke
Certain foods and preservatives in foods may trigger migraines in some people. Food-related triggers may include:
  • Any processed, fermented, pickled, or marinated foods
  • Baked goods
  • Chocolate
  • Dairy products
  • Foods containing monosodium glutamate (MSG)
  • Foods containing tyramine, which includes red wine, aged cheese, smoked fish, chicken livers, figs, and certain beans
  • Fruits (avocado, banana, citrus fruit)
  • Meats containing nitrates (bacon, hot dogs, salami, cured meats)
  • Nuts
  • Onions
  • Peanut butter
This list may not be all-inclusive.
True migraine headaches are not a result of a brain tumor or other serious medical problem. However, only an experienced health care provider can determine whether your symptoms are due to a migraine or another condition.

Tests & Diagnostics

Your doctor can diagnose this type of headache by asking questions about your symptoms and family history of migraines, and by monitoring how you respond to treatment. A complete physical exam will be done to make sure that your headaches are not due to muscle tension, sinus problems, or a more serious underlying brain disorder.


Tests are usually not needed if you have typical signs and symptoms of migraines. However, your doctor may order a brain MRI or CT scan to rule out other causes.


If you have a migraine with unusual symptoms such as weakness, memory problems, or loss of alertness, an EEG may be needed to rule out seizures. Rarely, a lumbar puncture (spinal tap) might be done.

reatments

There is no specific cure for migraine headaches. The goal is to prevent symptoms by avoiding or changing your triggers.


A good way to identify triggers is to keep a headache diary. Write down:
  • When your headaches occur
  • How severe they are
  • What you've eaten
  • How much sleep you had
  • Other symptoms
  • Other possible factors (women should note where they are in their menstrual cycle)
For example, the diary may reveal that your headaches tend to occur more often on days when you wake up earlier than usual. Changing your sleep schedule may result in fewer migraine attacks.


When you do get migraine symptoms, try to treat them right away. The headache may be less severe. When migraine symptoms begin:
  • Drink water to avoid dehydration, especially if you have vomited
  • Rest in a quiet, darkened room
  • Place a cool cloth on your head
Many different medications are available for people with migraines. Medicines are used to:
  • Reduce the number of attacks
  • Stop the migraine once early symptoms occur
  • Treat the pain and other symptoms
REDUCING ATTACKS
If you have frequent migraines, your doctor may prescribe medicine to reduce the number of attacks. Such medicine needs to be taken every day in order to be effective. Such medications may include:
  • Antidepressants such as amitriptyline
  • Blood pressure medicines such as beta blockers (propanolol) or calcium channel blockers (verapamil)
  • Seizure medication such as valproic acid and topiramate
  • Serotonin reuptake inhibitors (SSRIs) such as venlafaxine
STOPPING AN ATTACK
Other medicines are taken at the first sign of a migraine attack. Over-the-counter pain medications such as acetaminophen, ibuprofen, or aspirin are often helpful, especially when your migraine is mild. (Be aware, however, that overuse or misuse of such pain medications may result in rebound headaches.) If these don't help, ask your doctor about prescription medications.


Your doctor can select from several different types of medications, including:
These medications come in different forms. Patients who have nausea and vomiting with their migraines may be prescribed a nasal spray or injection instead of pills.


Some migraine medicines narrow your blood vessels and should not be used if you are at risk for heart attacks or have heart disease, unless otherwise instructed by your health care provider. Ergots should not be taken if you are pregnant or planning to become pregnant, because they can cause serious side effects to an unborn baby.


TREATING SYMPTOMS
Other medications are primarily given to treat the symptoms of migraine. Used alone or in combinations, these drugs can reduce your pain, nausea, or emotional distress. Medications in this group include:
If you wish to consider an alternative, feverfew is a popular herb for migraines. Several studies, but not all, support using feverfew for treating migraines. If you are interested in trying feverfew, make sure your doctor approves. Also, know that herbal remedies sold in drugstores and health food stores are not regulated. Work with a trained herbalist when selecting herbs.


Complications

Migraine headaches generally represent no significant threat to your overall health. However, they can be a long-term (chronic) problem and may interfere with your day-to-day life.

Prevention

Understanding your headache triggers can help you avoid foods and situations that cause your migraines. Keep a headache diary to help identify the source or trigger of your symptoms. Then modify your environment or habits to avoid future headaches.
Other tips for preventing migraines include:
  • Avoid smoking
  • Avoid alcohol
  • Avoid artificial sweeteners and other known food-related triggers
  • Get regular exercise
  • Get plenty of sleep each night
  • Learn to relax and reduce stress -- some patients have found that biofeedback and self-hypnosis helps reduce the number of migraine attacks
4:39 PM | 0 comments | Read More

What is Gastroesophageal Reflux Disease (GERD) ?

Written By share_e on Sunday, March 11, 2012 | 10:17 PM

Gastroesophageal reflux disease (GERD) is a condition in which the stomach contents (food or liquid) leak backwards from the stomach into the esophagus (the tube from the mouth to the stomach). This action can irritate the esophagus, causing heartburn and other symptoms.

Symptoms

More common symptoms are:
  • Feeling that food may be left trapped behind the breastbone
  • Heartburn or a burning pain in the chest (under the breastbone)
    • Increased by bending, stooping, lying down, or eating
    • More likely or worse at night
    • Relieved by antacids
  • Nausea after eating
Less common symptoms are:
  • Cough or wheezing
  • Difficulty swallowing
  • Hiccups
  • Hoarseness or change in voice
  • Regurgitation of food
  • Sore throat

Causes & Risk Factors

When you eat, food passes from the throat to the stomach through the esophagus (also called the food pipe or swallowing tube). Once food is in the stomach, a ring of muscle fibers prevents food from moving backward into the esophagus. These muscle fibers are called the lower esophageal sphincter, or LES.

If this sphincter muscle doesn't close well, food, liquid, and stomach acid can leak back into the esophagus. This is called reflux or gastroesophageal reflux. This reflux may cause symptoms, or can even damage the esophagus.

The risk factors for reflux include hiatal hernia (a condition in which part of the stomach moves above the diaphragm, which is the muscle that separates the chest and abdominal cavities), pregnancy, and scleroderma.

Obesity, cigarettes, and possibly alcohol also increase the chance of GERD.

Heartburn and gastroesophageal reflux can be brought on or worsened by pregnancy and many different medications. Such drugs include:
  • Anticholinergics (e.g., for seasickness)
  • Beta-blockers for high blood pressure or heart disease
  • Bronchodilators for asthma
  • Calcium channel blockers for high blood pressure
  • Dopamine-active drugs for Parkinson's disease
  • Progestin for abnormal menstrual bleeding or birth control
  • Sedatives for insomnia or anxiety
  • Tricyclic antidepressants
If you suspect that one of your medications may be causing heartburn, talk to your doctor. Never change or stop a medication you take regularly without talking to your doctor.

Tests & Diagnostics

You may not need any tests if your symptoms are not severe.

If your symptoms are severe or they come back after you have been treated, one or more tests may help diagnose reflux or any complications:
  • Esophagogastroduodenoscopy (EGD) is often used to identify the cause and examine the esophagus (swallowing tube) for damage. The doctor inserts a thin tube with a camera on the end through your mouth. The tube is then passed into your esophagus, stomach, and small intestine.
  • Barium swallow
  • Continuous esophageal pH monitoring
  • Esophageal manometry
A positive stool occult blood test may diagnose bleeding from the irritation in the esophagus.

Treatments

To prevent heartburn, avoid foods and beverages that may trigger your symptoms. For many people, these include:
  • Alcohol
  • Caffeine
  • Carbonated beverages
  • Chocolate
  • Citrus fruits and juices
  • Tomatoes
  • Tomato sauces
  • Spicy or fatty foods
  • Full-fat dairy products
  • Peppermint
  • Spearmint
If other foods regularly give you heartburn, avoid those foods, too.

Also, try the following changes to your eating habits and lifestyle:
  • Avoid bending over or exercising just after eating
  • Avoid garments or belts that fit tightly around your waist
  • Do not lie down with a full stomach. For example, avoid eating within 2 -3 hours of bedtime.
  • Do not smoke.
  • Eat smaller meals.
  • Lose weight if you are overweight.
  • Reduce stress.
  • Sleep with your head raised about 6 inches. Do this by tilting your entire bed, or by using a wedge under your body, not just with normal pillows.
Over-the-counter antacids may be used after meals and at bedtime, although they do not last very long. Common side effects of antacids include diarrhea or constipation.

Other over-the-counter and prescription drugs can treat GERD. They work more slowly than antacids but give you longer relief. Your doctor or nurse can tell you how to take these drugs.
  • Proton pump inhibitors (PPIs) are the most potent acid inhibitors: omeprazole (Prilosec), esomeprazole (Nexium), iansoprazole (Prevacid), rabeprazle (AcipHex), and pantoprazole (Protonix)
  • H2 antagonists: famotidine (Pepsid), cimetidine (Tagamet), ranitidine (Zantac), and nizatidine (Axid)
  • Promotility agents: metoclopramide (Reglan)
Anti-reflux operations (Nissen fundoplication and others) may be an option for patients whose symptoms do not go away with lifestyle changes and drugs. Heartburn and other symptoms should improve after surgery, but you may still need to take drugs for your heartburn. There are also new therapies for reflux that can be performed through an endoscope (a flexible tube passed through the mouth into the stomach).

Complications

  • Barrett's esophagus (a change in the lining of the esophagus that can increase the risk of cancer)
  • Bronchospasm (irritation and spasm of the airways due to acid)
  • Chronic cough or hoarseness
  • Dental problems
  • Esophageal ulcer
  • Inflammation of the esophagus
  • Stricture (a narrowing of the esophagus due to scarring from the inflammation)

Prevention

  • Heartburn prevention techniques
  • Looking at the esophagus with an endoscope and obtaining a sample of esophagus tissue for examination (esophagoscopy with biopsy) may be recommended to diagnose Barrett's esophagus.
  • Follow-up endoscopy to look for dysplasia or cancer is often advised.
10:17 PM | 0 comments | Read More

What is Diabetes ?

Diabetes is a chronic (lifelong) disease marked by high levels of sugar in the blood.

Causes, incidence, and risk factors

Insulin is a hormone produced by the pancreas to control blood sugar. Diabetes can be caused by too little insulin, resistance to insulin, or both.

To understand diabetes, it is important to first understand the normal process by which food is broken down and used by the body for energy. Several things happen when food is digested:
  • A sugar called glucose enters the bloodstream. Glucose is a source of fuel for the body.
  • An organ called the pancreas makes insulin. The role of insulin is to move glucose from the bloodstream into muscle, fat, and liver cells, where it can be used as fuel.
People with diabetes have high blood sugar. This is because:
  • Their pancreas does not make enough insulin
  • Their muscle, fat, and liver cells do not respond to insulin normally
  • Both of the above
There are three major types of diabetes:
  • Type 1 diabetes is usually diagnosed in childhood. Many patients are diagnosed when they are older than age 20. In this disease, the body makes little or no insulin. Daily injections of insulin are needed. The exact cause is unknown. Genetics, viruses, and autoimmune problems may play a role.
  • Type 2 diabetes is far more common than type 1. It makes up most of diabetes cases. It usually occurs in adulthood, but young people are increasingly being diagnosed with this disease. The pancreas does not make enough insulin to keep blood glucose levels normal, often because the body does not respond well to insulin. Many people with type 2 diabetes do not know they have it, although it is a serious condition. Type 2 diabetes is becoming more common due to increasing obesity and failure to exercise.
  • Gestational diabetes is high blood glucose that develops at any time during pregnancy in a woman who does not have diabetes. Women who have gestational diabetes are at high risk of type 2 diabetes and cardiovascular disease later in life.
Diabetes affects more than 20 million Americans. Over 40 million Americans have prediabetes (early type 2 diabetes).

There are many risk factors for type 2 diabetes, including:
  • Age over 45 years
  • A parent, brother, or sister with diabetes
  • Gestational diabetes or delivering a baby weighing more than 9 pounds
  • Heart disease
  • High blood cholesterol level
  • Obesity
  • Not getting enough exercise
  • Polycystic ovary disease (in women)
  • Previous impaired glucose tolerance
  • Some ethnic groups (particularly African Americans, Native Americans, Asians, Pacific Islanders, and Hispanic Americans)

Symptoms

High blood levels of glucose can cause several problems, including:
  • Blurry vision
  • Excessive thirst
  • Fatigue
  • Frequent urination
  • Hunger
  • Weight loss
However, because type 2 diabetes develops slowly, some people with high blood sugar experience no symptoms at all.
Symptoms of type 1 diabetes:
  • Fatigue
  • Increased thirst
  • Increased urination
  • Nausea
  • Vomiting
  • Weight loss in spite of increased appetite
Patients with type 1 diabetes usually develop symptoms over a short period of time. The condition is often diagnosed in an emergency setting.
Symptoms of type 2 diabetes:
  • Blurred vision
  • Fatigue
  • Increased appetite
  • Increased thirst
  • Increased urination

Signs and tests

A urine analysis may be used to look for glucose and ketones from the breakdown of fat. However, a urine test alone does not diagnose diabetes.
The following blood tests are used to diagnose diabetes:
  • Fasting blood glucose level -- diabetes is diagnosed if higher than 126 mg/dL on two occasions. Levels between 100 and 126 mg/dL are referred to as impaired fasting glucose or prediabetes. These levels are considered to be risk factors for type 2 diabetes and its complications.
  • Oral glucose tolerance test -- diabetes is diagnosed if glucose level is higher than 200 mg/dL after 2 hours. (This test is used more for type 2 diabetes.)
  • Random (non-fasting) blood glucose level -- diabetes is suspected if higher than 200 mg/dL and accompanied by the classic diabetes symptoms of increased thirst, urination, and fatigue. (This test must be confirmed with a fasting blood glucose test.)
Persons with diabetes need to have their hemoglobin A1c (HbA1c) level checked every 3 - 6 months. The HbA1c is a measure of average blood glucose during the previous 2 - 3 months. It is a very helpful way to determine how well treatment is working.

Treatment


The immediate goals are to treat diabetic ketoacidosis and high blood glucose levels. Because type 1 diabetes can start suddenly and have severe symptoms, people who are newly diagnosed may need to go to the hospital.
The long-term goals of treatment are to:
  • Prolong life
  • Reduce symptoms
  • Prevent diabetes-related complications such as blindness, heart disease, kidney failure, and amputation of limbs
These goals are accomplished through:
  • Blood pressure and cholesterol control
  • Careful self testing of blood glucose levels
  • Education
  • Exercise
  • Foot care
  • Meal planning and weight control
  • Medication or insulin use
There is no cure for diabetes. Treatment involves medicines, diet, and exercise to control blood sugar and prevent symptoms.

LEARN THESE SKILLS

Basic diabetes management skills will help prevent the need for emergency care. These skills include:
  • How to recognize and treat low blood sugar (hypoglycemia) and high blood sugar (hyperglycemia)
  • What to eat and when
  • How to take insulin or oral medication
  • How to test and record blood glucose
  • How to test urine for ketones (type 1 diabetes only)
  • How to adjust insulin or food intake when changing exercise and eating habits
  • How to handle sick days
  • Where to buy diabetes supplies and how to store them
After you learn the basics of diabetes care, learn how the disease can cause long-term health problems and the best ways to prevent these problems. Review and update your knowledge, because new research and improved ways to treat diabetes are constantly being developed.

SELF-TESTING

If you have diabetes, your doctor may tell you to regularly check your blood sugar levels at home. There are a number of devices available, and they use only a drop of blood. Self-monitoring tells you how well diet, medication, and exercise are working together to control your diabetes. It can help your doctor prevent complications.

The American Diabetes Association recommends keeping blood sugar levels in the range of:
  • 80 - 120 mg/dL before meals
  • 100 - 140 mg/dL at bedtime
Your doctor may adjust this depending on your circumstances.

WHAT TO EAT

You should work closely with your health care provider to learn how much fat, protein, and carbohydrates you need in your diet. A registered dietician can help you plan your dietary needs.

People with type 1 diabetes should eat at about the same times each day and try to be consistent with the types of food they choose. This helps to prevent blood sugar from becoming extremely high or low.

People with type 2 diabetes should follow a well-balanced and low-fat diet.

HOW TO TAKE MEDICATION

Medications to treat diabetes include insulin and glucose-lowering pills called oral hypoglycemic drugs.

People with type 1 diabetes cannot make their own insulin. They need daily insulin injections. Insulin does not come in pill form. Injections are generally needed one to four times per day. Some people use an insulin pump. It is worn at all times and delivers a steady flow of insulin throughout the day. Other people may use inhaled insulin. See also: Type 1 diabetes

Unlike type 1 diabetes, type 2 diabetes may respond to treatment with exercise, diet, and medicines taken by mouth. There are several types of medicines used to lower blood glucose in type 2 diabetes. See also: Type 2 diabetes

Medications may be switched to insulin during pregnancy and while breastfeeding.
Gestational diabetes may be treated with exercise and changes in diet.
 
EXERCISE

Regular exercise is especially important for people with diabetes. It helps with blood sugar control, weight loss, and high blood pressure. People with diabetes who exercise are less likely to experience a heart attack or stroke than those who do not exercise regularly.

Here are some exercise considerations:
  • Always check with your doctor before starting a new exercise program.
  • Ask your doctor or nurse if you have the right footwear.
  • Choose an enjoyable physical activity that is appropriate for your current fitness level.
  • Exercise every day, and at the same time of day, if possible.
  • Monitor blood glucose levels before and after exercise.
  • Carry food that contains a fast-acting carbohydrate in case you become hypoglycemic during or after exercise.
  • Carry a diabetes identification card and a cell phone in case of emergency.
  • Drink extra fluids that do not contain sugar before, during, and after exercise.
You may need to change your diet or medication dose if you change your exercise intensity or duration to keep blood sugar levels from going too high or low.

FOOT CARE

People with diabetes are more likely to have foot problems. Diabetes can damage blood vessels and nerves and decrease the body's ability to fight infection. You may not notice a foot injury until an infection develops. Death of skin and other tissue can occur.

If left untreated, the affected foot may need to be amputated. Diabetes is the most common condition leading to amputations.

To prevent injury to the feet, check and care for your feet every day.

Expectations (prognosis)

With good blood glucose and blood pressure control, many of the complications of diabetes can be prevented.
Studies have shown that strict control of blood sugar, cholesterol, and blood pressure levels in persons with diabetes helps reduce the risk of kidney disease, eye disease, nervous system disease, heart attack, and stroke.

Complications

Emergency complications include:
  • Diabetic hyperglycemic hyperosmolar coma
  • Diabetic ketoacidosis
Long-term complications include:
  • Atherosclerosis
  • Coronary artery disease
  • Diabetic nephropathy
  • Diabetic neuropathy
  • Diabetic retinopathy
  • Erection problems
  • Hyperlipidemia
  • Hypertension
  • Infections of the skin, female urinary tract, and urinary tract
  • Peripheral vascular disease
  • Stroke

Calling your health care provider

Go to the emergency room or call the local emergency number (such as 911) if you have symptoms of ketoacidosis:
  • Abdominal pain
  • Deep and rapid breathing
  • Increased thirst and urination
  • Loss of consciousness
  • Nausea
  • Sweet-smelling breath
Go to the emergency room or call the local emergency number (such as 911) if you have symptoms of extremely low blood sugar (hypoglycemic coma or severe insulin reaction):
  • Confusion
  • Convulsions or unconsciousness
  • Dizziness
  • Double vision
  • Drowsiness
  • Headache
  • Lack of coordination
  • Weakness

Prevention

Maintaining an ideal body weight and an active lifestyle may prevent type 2 diabetes.
Currently there is no way to prevent type 1 diabetes.

There is no effective screening test for type 1 diabetes in people who don't have symptoms.

Screening for type 2 diabetes and people with no symptoms is recommended for:
  • Overweight children who have other risk factors for diabetes starting at age 10 and repeating every 2 years
  • Overweight adults (BMI greater than 25) who have other risk factors
  • Adults over 45, repeated every 3 years
To prevent complications of diabetes, visit your health care provider or diabetes educator at least four times a year. Talk about any problems you are having.
Regularly have the following tests:
  • Have your blood pressure checked every year (blood pressure goals should be 130/80 mm/Hg or lower).
  • Have your glycosylated hemoglobin (HbA1c) checked every 6 months if your diabetes is well controlled, otherwise every 3 months.
  • Have your cholesterol and triglyceride levels checked yearly (aim for LDL levels below 100 mg/dL).
  • Get yearly tests to make sure your kidneys are working well (microalbuminuria and serum creatinine).
  • Visit your ophthalmologist (preferably one who specializes in diabetic retinopathy) at least once a year, or more often if you have signs of diabetic retinopathy.
  • See the dentist every 6 months for a thorough dental cleaning and exam. Make sure your dentist and hygienist know that you have diabetes.
  • Make sure your health care provider inspects your feet at each visit.
Stay up-to-date with all of your vaccinations and get a flu shot every year in the fall.
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